PhD Student (gn*) Immunology
Universitätsklinikum Münster
Kreisfreie Stadt Münster, 48 Münster, Deutschland
1.10.2025
Vollzeit
- To meet our high standards every day, we are looking forward to your scientific support at the Institute for Experimental Pathology - ideally with you on board!
- THE PROJECT:
- In a project funded by the IZKF (Interdisciplinary Centre for Clinical Research Münster), the newly established research group of Dr. Mariano Malamud is investigating the role of inhibitory receptors in the regulation of chronic inflammatory conditions. Inhibitory receptors are germline-encoded innate receptors that play a central role in maintaining immune homeostasis. Their loss or mutation is often associated with unchecked inflammation and destructive autoimmunity. This PhD project will focus on unraveling the specific role of a newly described inhibitory receptor that regulates cellular responses (Malamud et al., Nature 2024) in obesity and its associated metabolic disorders, with particular emphasis on atherosclerosis. The project builds on and complements the institute's expertise, led by Prof. Oliver Soehnlein, in understanding how neutrophils drive chronic sterile inflammation (Soehnlein et al., Nat Rev Immunol, 2017; Silvestre-Roig et al., Nature, 2019; Soehnlein & Libby, Nat Rev Drug Discov, 2021). Our institute offers a highly interdisciplinary and international environment and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics.
- Design and conduct experiments utilizing state-of-the-art approaches such as:
- Animal models of metabolic diseases and atherosclerosis
- Flow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometry
- Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry
- Biochemical assays for cytokines and other inflammatory mediators
- Cell culture experiments (primary cells and cell lines)
- Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology
- Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
- Contribute to manuscript preparation
- Participate actively in departmental seminars, workshops, and conferences
- Part of Research Innovation
Berufserfahrung
- Erste Berufserfahrung
- Mehrjährige Berufserfahrung